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Urol Oncol. 2013 Oct;31(7):1012-21. doi: 10.1016/j.urolonc.2011.10.004. Epub 2011 Dec 7.

The Personal Patient Profile-Prostate decision support for men with localized prostate cancer: a multi-center randomized trial.

Author information

  • 1Dana-Farber Cancer Institute, Phyllis F. Cantor Center, Boston, MA 02215, USA. Electronic address: donna_berry@dfci.harvard.edu.

Abstract

OBJECTIVE:

The purpose of this trial was to compare usual patient education plus the Internet-based Personal Patient Profile-Prostate, vs. usual education alone, on conflict associated with decision making, plus explore time-to-treatment, and treatment choice.

METHODS:

A randomized, multi-center clinical trial was conducted with measures at baseline, 1-, and 6 months. Men with newly diagnosed localized prostate cancer (CaP) who sought consultation at urology, radiation oncology, or multi-disciplinary clinics in 4 geographically-distinct American cities were recruited. Intervention group participants used the Personal Patient Profile-Prostate, a decision support system comprised of customized text and video coaching regarding potential outcomes, influential factors, and communication with care providers. The primary outcome, patient-reported decisional conflict, was evaluated over time using generalized estimating equations to fit generalized linear models. Additional outcomes, time-to-treatment, treatment choice, and program acceptability/usefulness, were explored.

RESULTS:

A total of 494 eligible men were randomized (266 intervention; 228 control). The intervention reduced adjusted decisional conflict over time compared with the control group, for the uncertainty score (estimate -3.61; (confidence interval, -7.01, 0.22), and values clarity (estimate -3.57; confidence interval (-5.85,-1.30). Borderline effect was seen for the total decisional conflict score (estimate -1.75; confidence interval (-3.61,0.11). Time-to-treatment was comparable between groups, while undecided men in the intervention group chose brachytherapy more often than in the control group. Acceptability and usefulness were highly rated.

CONCLUSION:

The Personal Patient Profile-Prostate is the first intervention to significantly reduce decisional conflict in a multi-center trial of American men with newly diagnosed localized CaP. Our findings support efficacy of P3P for addressing decision uncertainty and facilitating patient selection of a CaP treatment that is consistent with the patient values and preferences.

Copyright © 2013 Elsevier Inc. All rights reserved.

KEYWORDS:

Decision making; Decisional conflict; Internet; Prostate cancer; Randomized trial

PMID:
22153756
[PubMed - indexed for MEDLINE]
PMCID:
PMC3349002
Free PMC Article
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