Display Settings:

Format

Send to:

Choose Destination
Trends Microbiol. 2012 Jan;20(1):50-7. doi: 10.1016/j.tim.2011.11.002. Epub 2011 Dec 5.

The pig: a model for human infectious diseases.

Author information

  • 1Institut National de la Recherche Agronomique, Unité de Recherche 1282, Infectiologie Animale et Santé Publique, 37380, Nouzilly (Tours), France. meurens@tours.inra.fr

Abstract

An animal model to study human infectious diseases should accurately reproduce the various aspects of disease. Domestic pigs (Sus scrofa domesticus) are closely related to humans in terms of anatomy, genetics and physiology, and represent an excellent animal model to study various microbial infectious diseases. Indeed, experiments in pigs are much more likely to be predictive of therapeutic treatments in humans than experiments in rodents. In this review, we highlight the numerous advantages of the pig model for infectious disease research and vaccine development and document a few examples of human microbial infectious diseases for which the use of pigs as animal models has contributed to the acquisition of new knowledge to improve both animal and human health.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
22153753
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk