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Cell Metab. 2011 Dec 7;14(6):722-3. doi: 10.1016/j.cmet.2011.11.009.

Of mice and men: not ExAKTly the same?

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  • 1The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA.


The serine-threonine protein kinase Akt2, also known as PKBβ, has been shown to regulate glucose and lipid metabolism in animal models. In a recent study published in Science, Hussain et al. (2011) report that in human subjects an activating mutation of Akt2 leads to hypoglycemia and, unexpectedly, asymmetric overgrowth.

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