Chest. 2011 Dec;140(6):1408-13; discussion 1413-9.

Counterpoint: should lactate clearance be substituted for central venous oxygen saturation as goals of early severe sepsis and septic shock therapy? No.

Rivers EP, Elkin R, Cannon CM.

Comment on

Chest. 2011 Dec;140(6):1406-8.

PMID:: 22147818; [PubMed - indexed for MEDLINE]
PMCID:: PMC3244279; [Available on 2012/12/1]

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Point: should lactate clearance be substituted for central venous oxygen saturation as goals of early severe sepsis and septic shock therapy? Yes. [Chest. 2011]
Point: should lactate clearance be substituted for central venous oxygen saturation as goals of early severe sepsis and septic shock therapy? Yes.
Jones AE. Chest. 2011 Dec; 140(6):1406-8.
Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. [JAMA. 2010]
Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial.
Jones AE, Shapiro NI, Trzeciak S, Arnold RC, Claremont HA, Kline JA, Emergency Medicine Shock Research Network (EMShockNet) Investigators. JAMA. 2010 Feb 24; 303(8):739-46.
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Park M, Azevedo LC, Maciel AT, Pizzo VR, Noritomi DT, da Cruz Neto LM. Clinics (Sao Paulo). 2006 Feb; 61(1):47-52. Epub 2006 Mar 10.
Review Hemodynamic and perfusion end points for volemic resuscitation in sepsis. [Shock. 2010]
Review Hemodynamic and perfusion end points for volemic resuscitation in sepsis.
da Silva Ramos FJ, Azevedo LC. Shock. 2010 Sep; 34 Suppl 1:34-9.
Review Early goal-directed therapy: an evidence-based review. [Crit Care Med. 2004]
Review Early goal-directed therapy: an evidence-based review.
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Counterpoint: should lactate clearance be substituted for central venous oxygen saturation as goals of early severe sepsis and septic shock therapy? No.

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