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Immunopharmacol Immunotoxicol. 2012 Jun;34(3):373-8. doi: 10.3109/08923973.2011.608360. Epub 2011 Dec 6.

A quantitative description of the peptide sharing between poliovirus and Homo sapiens.

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  • 1Department of Biochemistry and Molecular Biology, University of Bari, Italy.


In the present study, we analyze the peptide commonality between poliovirus polyprotein and the human proteins. We report on the following findings: (1) the extent of polio peptide overlap on the human proteome is high, and involves the entire viral polyprotein; (2) viral peptide matching affects human proteins linked to fundamental cellular functions. The data may help to further our understanding of the relationships between poliovirus and the human host.

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