Warning: The NCBI web site requires JavaScript to function. more...
Generate a file for use with external citation management software.
Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA. Hya.yin.myint@us.army.mil
Because 8-aminoquinolines affect critical survival stages of Plasmodium parasites, treatment and control of malaria could be markedly improved by more widespread use of these drugs; however, hemolytic toxicity, which is widely prevalent in G6PD-deficient patients, severely constrains this use. Primaquine was approved more than 50 years ago after extensive clinical testing. Review of the mid-20th century literature in the light of present understanding of pharmacokinetics and metabolism suggests that manipulation of these factors might dissociate 8-aminoquinoline efficacy from toxicity and lead to an improved therapeutic index.
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on