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Methods Mol Biol. 2012;804:463-79. doi: 10.1007/978-1-61779-361-5_23.

Logical modelling of gene regulatory networks with GINsim.

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  • 1Instituto Gulbenkian de Ciência, Oeiras, Portugal. chaouira@igc.gulbenkian.pt

Abstract

Discrete mathematical formalisms are well adapted to model large biological networks, for which detailed kinetic data are scarce. This chapter introduces the reader to a well-established qualitative (logical) framework for the modelling of regulatory networks. Relying on GINsim, a software implementing this logical formalism, we guide the reader step by step towards the definition and the analysis of a simple model of the lysis-lysogeny decision in the bacteriophage λ.

PMID:
22144167
[PubMed - indexed for MEDLINE]
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