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    Antimicrob Agents Chemother. 2012 Feb;56(2):883-6. Epub 2011 Dec 5.

    Aerosolized gentamicin reduces the burden of tuberculosis in a murine model.

    Roy CJ, Sivasubramani SK, Dutta NK, Mehra S, Golden NA, Killeen S, Talton JD, Hammoud BE, Didier PJ, Kaushal D.

    Source

    Divisions of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA.

    Erratum in

    • Antimicrob Agents Chemother. 2012 Mar;56(3):1672.

    Abstract

    Tuberculosis (TB) is a major infectious disease problem: 1.7 million people annually die due to TB. Emergence of drug-resistant Mycobacterium tuberculosis and the lack of new antibiotics have exacerbated the situation. There is an urgent need to develop or repurpose drugs against TB. We evaluated inhaled gentamicin as direct respiratory system-targeted therapy in a murine model of TB. Aerosolized-gentamicin-treated mice showed significantly reduced lung M. tuberculosis loads and fewer granulomas relative to untreated controls. These results suggest that direct delivery of antibiotics to the respiratory system may provide therapeutic benefit to conventional treatment regimes for treatment of pulmonary TB.

    PMID:
    22143521
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3264242
    [Available on 2012/8/1]

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