Send to

Choose Destination
See comment in PubMed Commons below
J Intern Med. 2012 Feb;271(2):131-41. doi: 10.1111/j.1365-2796.2011.02494.x.

Using the reconstructed genome-scale human metabolic network to study physiology and pathology.

Author information

  • 1Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.


Metabolism plays a key role in many major human diseases. Generation of high-throughput omics data has ushered in a new era of systems biology. Genome-scale metabolic network reconstructions provide a platform to interpret omics data in a biochemically meaningful manner. The release of the global human metabolic network, Recon 1, in 2007 has enabled new systems biology approaches to study human physiology, pathology and pharmacology. There are currently more than 20 publications that utilize Recon 1, including studies of cancer, diabetes, host-pathogen interactions, heritable metabolic disorders and off-target drug binding effects. In this mini-review, we focus on the reconstruction of the global human metabolic network and four classes of its application. We show that computational simulations for numerous pathologies have yielded clinically relevant results, many corroborated by existing or newly generated experimental data.

© 2011 The Association for the Publication of the Journal of Internal Medicine.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Write to the Help Desk