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Cell Stem Cell. 2011 Dec 2;9(6):493-5. doi: 10.1016/j.stem.2011.11.016.

Blood cells need glia, too: a new role for the nervous system in the bone marrow niche.

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  • 1Department of Cell and Tissue Biology, Department of Anatomy, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143-0669, USA.


Regulation of hematopoietic stem cell (HSC) dormancy by specific cell types in the hematopoietic niche remains poorly understood. Yamazaki et al. (2011) now report that nerve-associated nonmyelinating Schwann cells activate TGF-β to maintain dormant HSCs, suggesting that glia are novel players in the bone marrow niche.

Copyright © 2011 Elsevier Inc. All rights reserved.

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