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BMC Neurol. 2011 Dec 2;11:151. doi: 10.1186/1471-2377-11-151.

Behavioral effects of congenital ventromedial prefrontal cortex malformation.

Author information

  • 1Department of Pediatric Neurology, Massachusetts General Hospital, Harvard University, Boston, MA 02114, USA. aboes@partners.org

Abstract

BACKGROUND:

A detailed behavioral profile associated with focal congenital malformation of the ventromedial prefrontal cortex (vmPFC) has not been reported previously. Here we describe a 14 year-old boy, B.W., with neurological and psychiatric sequelae stemming from focal cortical malformation of the left vmPFC.

CASE PRESENTATION:

B.W.'s behavior has been characterized through extensive review Patience of clinical and personal records along with behavioral and neuropsychological testing. A central feature of the behavioral profile is severe antisocial behavior. He is aggressive, manipulative, and callous; features consistent with psychopathy. Other problems include: egocentricity, impulsivity, hyperactivity, lack of empathy, lack of respect for authority, impaired moral judgment, an inability to plan ahead, and poor frustration tolerance.

CONCLUSIONS:

The vmPFC has a profound contribution to the development of human prosocial behavior. B.W. demonstrates how a congenital lesion to this cortical region severely disrupts this process.

PMID:
22136635
[PubMed - indexed for MEDLINE]
PMCID:
PMC3265436
Free PMC Article

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