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J Comp Neurol. 2012 Jun 15;520(9):1940-50. doi: 10.1002/cne.23019.

Kv7.5 is the primary Kv7 subunit expressed in C-fibers.

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  • 1Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. chking@mail.med.upenn.edu


Kv7 (KCNQ) potassium channel openers (enhancers) decrease neuropathic pain in experimental models. Here we show that C-fibers, and their associated small-diameter neurons in the dorsal root ganglia (both IB4- and TrkA-positive), expressed Kv7.5. In contrast, C-fibers did not express detectable levels of Kv7.2 or Kv7.3, which are instead localized to nodes of Ranvier and the cell bodies of large sensory neurons. These data suggest that Kv7.5 provides the primary M current in nociceptive neurons.

Copyright © 2011 Wiley Periodicals, Inc.

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