Mol Divers. 2012 Feb;16(1):151-6. Epub 2011 Dec 2.

Spiro[pyrrolidine-2,3'-oxindole] derivatives synthesized by novel regionselective 1,3-dipolar cycloadditions.

Chen G, Yang J, Gao S, He H, Li S, Di Y, Chang Y, Lu Y, Hao X.

Source

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, China. gangchen@xsyu.edu.cn

Abstract

A series of spiro-oxindole derivatives was synthesized by novel regioselective 1,3-dipolar cycloadditions of isatin, α-amino acids, and (E)-β-aryl-nitro-olefins. Regioisomers were produced in each reaction and the major products showed different regioselectivity compared to previously reported spiro-oxindole derivatives.

PMID:: 22134725; [PubMed - in process]

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Spiro[pyrrolidine-2,3'-oxindole] derivatives synthesized by novel regionselective 1,3-dipolar cycloadditions.

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