Abstract
A Gd(3+) based paramagnetic dextran conjugate has been developed, which enables the tracking of neuroanatomical connectivity in the brain by both MR and optical imaging. Cell studies and subsequent in vivo experiments in rodents demonstrate efficient internalisation and transport properties of the new tracer molecule.
This journal is © The Royal Society of Chemistry 2012
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain / physiology*
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Cell Line, Tumor
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Contrast Media / chemistry*
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Contrast Media / pharmacokinetics
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Coordination Complexes / chemistry*
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Coordination Complexes / pharmacokinetics
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Dextrans / chemistry
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Gadolinium / chemistry
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Magnetic Resonance Imaging
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Mice
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Microscopy, Fluorescence
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Neuronal Plasticity / physiology*
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Rats
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Rats, Sprague-Dawley
Substances
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Contrast Media
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Coordination Complexes
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Dextrans
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Gadolinium