Dual-functional probes towards in vivo studies of brain connectivity and plasticity

Chem Commun (Camb). 2012 Mar 14;48(22):2755-7. doi: 10.1039/c1cc15991g. Epub 2011 Dec 1.

Abstract

A Gd(3+) based paramagnetic dextran conjugate has been developed, which enables the tracking of neuroanatomical connectivity in the brain by both MR and optical imaging. Cell studies and subsequent in vivo experiments in rodents demonstrate efficient internalisation and transport properties of the new tracer molecule.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / physiology*
  • Cell Line, Tumor
  • Contrast Media / chemistry*
  • Contrast Media / pharmacokinetics
  • Coordination Complexes / chemistry*
  • Coordination Complexes / pharmacokinetics
  • Dextrans / chemistry
  • Gadolinium / chemistry
  • Magnetic Resonance Imaging
  • Mice
  • Microscopy, Fluorescence
  • Neuronal Plasticity / physiology*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Contrast Media
  • Coordination Complexes
  • Dextrans
  • Gadolinium