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J Clin Invest. 2011 Dec;121(12):4600-9. doi: 10.1172/JCI57148. Epub 2011 Dec 1.

HSV-2: in pursuit of a vaccine.

Author information

  • 1Department of Medicine, University of Washington, Seattle, Washington, USA. cjohnsto@u.washington.edu

Abstract

Herpes simplex virus type 2 (HSV-2) is one of the most prevalent sexually transmitted infections worldwide. In addition to recurrent genital ulcers, HSV-2 causes neonatal herpes, and it is associated with a 3-fold increased risk for HIV acquisition. Although many HSV-2 vaccines have been studied in animal models, few have reached clinical trials, and those that have been tested in humans were not consistently effective. Here, we review HSV-2 pathogenesis, with a focus on novel understanding of mucosal immunobiology of HSV-2, and vaccine efforts to date, in an attempt to stimulate thinking about future directions for development of effective prophylactic and therapeutic HSV-2 vaccines.

PMID:
22133885
[PubMed - indexed for MEDLINE]
PMCID:
PMC3223069
Free PMC Article
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