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Eur J Med Chem. 2012 Jan;47(1):608-14. doi: 10.1016/j.ejmech.2011.10.045. Epub 2011 Nov 3.

Isoxazoles incorporated N-substituted decahydroquinolines: a precursor to the next generation antimicrobial drug.

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  • 1Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Palkalai Nagar, Madurai 625 021, Tamilnadu, India.


We report here a simple entry into N-substituted decahydroisoxazoloquinoline system with substituents at position 3 and 4 from the readily available substrates for the first time. The synthesized isoxazoloquinolines were evaluated against six bacterial and four fungal strains. The results suggest that the decahydroisoxazolo[4,3-c]quinoline scaffold has the potential to be developed into therapeutically useful antimicrobial agents.

Copyright © 2011 Elsevier Masson SAS. All rights reserved.

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