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Nefrologia. 2011;31(6):707-15. doi: 10.3265/Nefrologia.pre2011.Sep.11089.

Relationship between serum phosphorus and the progression of advanced chronic kidney disease.

[Article in English, Spanish]

Author information

  • 1Nephrology Department, Infanta Cristina Hospital, Avda. Elvas s/n, Badajoz, Spain. fcaravacam@senefro.org

Abstract

INTRODUCTION:

High serum phosphorus (P) has been shown to be associated with a more rapid decline of renal function in patients with chronic kidney disease (CKD).

OBJECTIVE:

The aim of this study was to determine whether time-averaged serum P levels are associated with the progression of renal failure adjusted for other potential confounders.

PATIENTS AND METHODS:

A prospective observational study of 184 patients with pre-dialysis CKD, stages 3, 4 and 5 (mean GFR=15.2±5.6 ml/min/1.73 m2). The rate of decline in renal function was calculated as the slope of GFR. Median follow-up time was 303 days. Biochemical parameters were analysed as time-averaged concentrations. Multivariate linear regression analysis was used to assess the best determinants of serum P levels, and the relationship between the rate of decline of renal function and the study covariates.

RESULTS:

The best determinants of serum P levels were: GFR (beta = 0.477), female sex (beta = 0.106), serum calcium (beta = -0.274), serum albumin (beta = -0.112), serum bicarbonate (beta = -0.182), protein catabolic rate (beta = 0.144), and use of diuretics (beta = 0.180). The mean ± standard deviation (SD) slope of GFR was -0.198±0.376 ml/min/month. The best determinants of the slope of GFR were: proteinuria (beta = -0.462), serum P (beta = -0.440), and basal GFR (beta = -0.404). Total urinary P excretion was not significantly associated with the rate of decline of renal function.

CONCLUSION:

High serum P levels are strongly and independently associated with a more rapid decline of renal function in patients with advanced CKD.

PMID:
22130287
[PubMed - indexed for MEDLINE]
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