Science. 1977 Dec 9;198(4321):1063-5.

Cytidine 3',5'-monophosphate (cyclic CMP) formation in mammalian tissues.

Abstract

Mammalian tissues possess the capacity to synthesize cytidine 3',5'-monopHosphate (cyclic CMP) via the enzymatic conversion of cytidine 5'-triphosphate to cyclic CMP by cytidylate cyclase. Cyclic CMP formation occurs best in the presence of manganese or iron, at neutral pH, at 37 degrees C, in the absence of detergents, and with whole tissue homogenate fractions. Thus, mammalian tissues are capable of synthesizing not only cyclic AMP and cyclic GMP, but also cyclic CMP.

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Cytidylate cyclase activity in mouse tissues: the enzymatic conversion of cytidine 5'-triphosphate to cytidine 3',5'-cyclic monophosphate (cyclic CMP). [Biochim Biophys Acta. 1989]
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Cited by 5 PubMed Central articles

Conversion of 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine to cidofovir by an intracellular cyclic CMP phosphodiesterase. [Antimicrob Agents Chemother. 1...]
Conversion of 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine to cidofovir by an intracellular cyclic CMP phosphodiesterase.
Mendel DB, Cihlar T, Moon K, Chen MS. Antimicrob Agents Chemother. 1997 Mar; 41(3):641-6.
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Extraction, purification and identification of cytidine 3',5'-cyclic monophosphate from rat tissues.
Newton RP, Salih SG, Salvage BJ, Kingston EE. Biochem J. 1984 Aug 1; 221(3):665-73.
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Cytidine 3',5'-monophosphate (cyclic CMP) formation in mammalian tissues.

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Cited by 5 PubMed Central articles

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