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Phytochem Lett. 2011 Dec;4(4):411-414.

Chlorinated Withanolides from Withania somnifera.

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  • 1Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66045, United States.

Abstract

A chlorinated withanolide, 6α-chloro-5β,17α-dihydroxywithaferin A (1), and nine known withanolides, 6α-chloro-5β-hydroxywithaferin A (2), (22R)-5β-formyl-6β,27-dihydroxy-1-oxo-4-norwith-24-enolide, withaferin A, 2,3-dihydrowithaferin A, 3-methoxy-2,3-dihydrowithaferin A, 2,3-didehydrosomnifericin, withanone, withanoside IV and withanoside X, were isolated from Withania somnifera (Solanaceae). All structures were elucidated on the basis of spectroscopic methods (IR, HRESIMS, 1D/2D NMR). X-ray crystallography confirmed the absolute configuration of 1.

PMID:
22125584
[PubMed]
PMCID:
PMC3223914
Free PMC Article

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