J Am Acad Dermatol. 1990 Aug;23(2 Pt 1):263-8.

Platelet activating factor-induced clinical and histopathologic responses in atopic skin and their modification by the platelet activating factor antagonist BN52063.

Markey AC, Barker JN, Archer CB, Guinot P, Lee TH, MacDonald DM.

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Department of Dermatology, United Medical School, Guy's Hospital, London, U.K.

Abstract

The clinical and histopathologic responses to intradermal platelet-activating factor (PAF-acether) in atopic subjects, without evidence of atopic dermatitis are documented. An immediate acute wheal and flare reaction was observed in all volunteers. Histopathologically, the reaction was characterized by a predominantly neutrophilic response, which was seen at 30 minutes and was maximal at 4 hours. Eosinophils were observed in the infiltrate as early as 30 minutes after injection, and were maximal by 12 hours. The specific PAF-acether antagonist BN52063 antagonized the acute flare response to intradermal PAF-acether but had little effect on cellular recruitment at the site of injection.

PMID:: 2212123; [PubMed - indexed for MEDLINE]

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Effect of a PAF antagonist, BN52063, on antigen-induced, acute, and late-onset cutaneous responses in atopic subjects. [J Allergy Clin Immunol. 1988]
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