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Nat Cell Biol. 2011 Nov 27;14(1):93-105. doi: 10.1038/ncb2383.

Defining human ERAD networks through an integrative mapping strategy.

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  • 1Department of Biology & Bio-X Program, Stanford University, Stanford, California 94305, USA.

Abstract

Proteins that fail to correctly fold or assemble into oligomeric complexes in the endoplasmic reticulum (ER) are degraded by a ubiquitin- and proteasome-dependent process known as ER-associated degradation (ERAD). Although many individual components of the ERAD system have been identified, how these proteins are organized into a functional network that coordinates recognition, ubiquitylation and dislocation of substrates across the ER membrane is not well understood. We have investigated the functional organization of the mammalian ERAD system using a systems-level strategy that integrates proteomics, functional genomics and the transcriptional response to ER stress. This analysis supports an adaptive organization for the mammalian ERAD machinery and reveals a number of metazoan-specific genes not previously linked to ERAD.

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PMID:
22119785
[PubMed - indexed for MEDLINE]
PMCID:
PMC3250479
Free PMC Article

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