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Vaccine. 2012 Jan 11;30(3):607-13. doi: 10.1016/j.vaccine.2011.11.048. Epub 2011 Nov 23.

Model for competition from self during passive immunization, with application to broadly neutralizing antibodies for HIV.

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  • 1James Franck Institute, The University of Chicago, Chicago, IL 60637, United States.

Abstract

We propose a mathematical model to interpret observations concerning the behavior of broadly neutralizing antibodies for chronic HIV in vivo. The model enables us to identify a threshold antibody level that must be achieved to decrease the viral load effectively. Although this threshold has not been reached in existing passive immunization studies, it is within range of humoral immune responses, suggesting that therapeutic vaccines are feasible. In an appendix, we develop a model of passive immunization against influenza, and acute infection.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
22119591
[PubMed - indexed for MEDLINE]
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