Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Biol. 2011 Dec 6;21(23):2000-5. doi: 10.1016/j.cub.2011.10.022. Epub 2011 Nov 23.

Wiring economy and volume exclusion determine neuronal placement in the Drosophila brain.

Author information

  • 1Instituto Cajal, CSIC, Av. Doctor Arce 37, 28002 Madrid, Spain.

Erratum in

  • Curr Biol. 2012 Jan 24;22(2):172. Mischenko, Yuriy [corrected to Mishchenko, Yuriy].

Abstract

Wiring economy has successfully explained the individual placement of neurons in simple nervous systems like that of Caenorhabditis elegans [1-3] and the locations of coarser structures like cortical areas in complex vertebrate brains [4]. However, it remains unclear whether wiring economy can explain the placement of individual neurons in brains larger than that of C. elegans. Indeed, given the greater number of neuronal interconnections in larger brains, simply minimizing the length of connections results in unrealistic configurations, with multiple neurons occupying the same position in space. Avoiding such configurations, or volume exclusion, repels neurons from each other, thus counteracting wiring economy. Here we test whether wiring economy together with volume exclusion can explain the placement of neurons in a module of the Drosophila melanogaster brain known as lamina cartridge [5-13]. We used newly developed techniques for semiautomated reconstruction from serial electron microscopy (EM) [14] to obtain the shapes of neurons, the location of synapses, and the resultant synaptic connectivity. We show that wiring length minimization and volume exclusion together can explain the structure of the lamina microcircuit. Therefore, even in brains larger than that of C. elegans, at least for some circuits, optimization can play an important role in individual neuron placement.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
22119527
[PubMed - indexed for MEDLINE]
PMCID:
PMC3244492
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk