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Br J Haematol. 2012 Feb;156(3):354-7. doi: 10.1111/j.1365-2141.2011.08946.x. Epub 2011 Nov 25.

Integrated DNA copy number and methylation profiling of lymphoid neoplasms using a single array.

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  • 1Institute of Oncology Research (IOR) and Oncology Institute of Southern Switzerland. ivo.kwee@irb.unisi.ch


Changes in DNA copy number (CN) and DNA methylation represent important aberrations for lymphomas and other cancers. Here, for the first time, we show that the Illumina Infinium Methylation (IIM) assay, although not originally designed for CN profiling, is able to estimate CN changes. We compared the IIM CN profiles to those obtained with a standard technique in a series of diffuse large B-cell lymphomas: the profiles showed a high degree of consensus. The demonstration of CN profiling as an additional function of the IIM assay may impact the choice of platform for methylation profiling of haematological and solid tumours.

© 2011 Blackwell Publishing Ltd.

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