Anti-/Propsychotic drug signaling via heteromeric GPCRs--a balancing act?

Mari Kondo; Akira Sawa

doi:10.1016/j.cell.2011.11.012

Anti-/Propsychotic drug signaling via heteromeric GPCRs--a balancing act?

Cell. 2011 Nov 23;147(5):964-5. doi: 10.1016/j.cell.2011.11.012.

Authors

Mari Kondo¹, Akira Sawa

Affiliation

¹ Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. asawa1@jhmi.edu

PMID: 22118451
DOI: 10.1016/j.cell.2011.11.012

Abstract

In this issue, Fribourg et al. provide insight into a molecular basis of psychosis. They reveal that a heteromeric complex formed by the G protein-coupled receptors (GPCRs) for glutamate and serotonin is a convergent site for the activity of anti- or propsychotic drugs, opening a possibility for new therapeutic strategies for schizophrenia.

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