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J Neuroimmunol. 2012 Jan 18;242(1-2):1-8. doi: 10.1016/j.jneuroim.2011.10.012. Epub 2011 Nov 23.

Substance P-neurokinin-1 receptor interaction upregulates monocyte tissue factor.

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  • 1Department of Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, United States.


Monocytes play an important role in hemostasis. In this study, the prothrombotic effects of the neuropeptide substance P (SP) on human monocytes through neurokinin-1 receptor (NK1-R) were characterized. SP upregulated monocyte tissue factor (TF), the major coagulation cascade stimulator, in a concentration and time dependent manner. Specific inhibition of NK1-R completely blocked TF expression. Monocytes stimulated by SP released cytokines and chemokines. When monocytes were stimulated with cytokines or chemokines, TF was expressed by the cytokines (GM-CSF, IFN-γ and TNF-α). Cytokines may play a major role in the mechanism of SP induced monocyte TF expression. NK1-R antagonists (NK1-RA) may have a role in developing novel therapeutic approaches to patients vulnerable to vaso-occlusive disorders.

Copyright © 2011 Elsevier B.V. All rights reserved.

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