J Bacteriol. 1990 Oct;172(10):5852-5.

Minicell-forming mutants of Escherichia coli: suppression of both DicB- and MinD-dependent division inhibition by inactivation of the minC gene product.

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Centre de Recherches de Biochimie et de Génétique cellulaires du Centre National de la Recherche Scientifique, Toulouse, France.

Abstract

We have determined the nucleotide sequence of the minB operon of 10 min mutants of Escherichia coli, characterized by impaired inhibition of polar divisions. These mutants were either sensitive or resistant to the division inhibitor DicB. All the mutations were found to lie in minC or minD, confirming the requirement of both gene products in the process of inhibition of polar sites. Mutations conferring resistance to inhibitor DicB were found exclusively in minC. In agreement with de Boer et al. (P. A. J. de Boer, R. E. Crossley, and L. I. Rothfield, Proc. Natl. Acad. Sci. USA 87:1129-1133, 1990), these results provide evidence that, in addition to promoting division inhibition with MinD, protein MinC acts in concert with DicB to inhibit division by a second, MinD-independent process.

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Central role for the Escherichia coli minC gene product in two different cell division-inhibition systems. [Proc Natl Acad Sci U S A. 1990]
Central role for the Escherichia coli minC gene product in two different cell division-inhibition systems.
de Boer PA, Crossley RE, Rothfield LI. Proc Natl Acad Sci U S A. 1990 Feb; 87(3):1129-33.
New minC mutations suggest different interactions of the same region of division inhibitor MinC with proteins specific for minD and dicB coinhibition pathways. [J Bacteriol. 1992]
New minC mutations suggest different interactions of the same region of division inhibitor MinC with proteins specific for minD and dicB coinhibition pathways.
Mulder E, Woldringh CL, Tétart F, Bouché JP. J Bacteriol. 1992 Jan; 174(1):35-9.
A division inhibitor and a topological specificity factor coded for by the minicell locus determine proper placement of the division septum in E. coli. [Cell. 1989]
A division inhibitor and a topological specificity factor coded for by the minicell locus determine proper placement of the division septum in E. coli.
de Boer PA, Crossley RE, Rothfield LI. Cell. 1989 Feb 24; 56(4):641-9.
MinC mutants deficient in MinD- and DicB-mediated cell division inhibition due to loss of interaction with MinD, DicB, or a septal component. [J Bacteriol. 2005]
MinC mutants deficient in MinD- and DicB-mediated cell division inhibition due to loss of interaction with MinD, DicB, or a septal component.
Zhou H, Lutkenhaus J. J Bacteriol. 2005 Apr; 187(8):2846-57.
Isolation and mapping of Escherichia coli mutations conferring resistance to division inhibition protein DicB. [J Bacteriol. 1989]
Isolation and mapping of Escherichia coli mutations conferring resistance to division inhibition protein DicB.
Labie C, Bouché F, Bouché JP. J Bacteriol. 1989 Aug; 171(8):4315-9.

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Cited by 20 PubMed Central articles

The CnuK9E H-NS complex antagonizes DNA binding of DicA and leads to temperature-dependent filamentous growth in E. coli. [PLoS One. 2012]
The CnuK9E H-NS complex antagonizes DNA binding of DicA and leads to temperature-dependent filamentous growth in E. coli.
Yun SH, Ji SC, Jeon HJ, Wang X, Kim SW, Bak G, Lee Y, Lim HM. PLoS One. 2012; 7(9):e45236. Epub 2012 Sep 13.
MinC mutants deficient in MinD- and DicB-mediated cell division inhibition due to loss of interaction with MinD, DicB, or a septal component. [J Bacteriol. 2005]
MinC mutants deficient in MinD- and DicB-mediated cell division inhibition due to loss of interaction with MinD, DicB, or a septal component.
Zhou H, Lutkenhaus J. J Bacteriol. 2005 Apr; 187(8):2846-57.
Conserved glycines in the C terminus of MinC proteins are implicated in their functionality as cell division inhibitors. [J Bacteriol. 2004]
Conserved glycines in the C terminus of MinC proteins are implicated in their functionality as cell division inhibitors.
Ramirez-Arcos S, Greco V, Douglas H, Tessier D, Fan D, Szeto J, Wang J, Dillon JR. J Bacteriol. 2004 May; 186(9):2841-55.

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Minicell-forming mutants of Escherichia coli: suppression of both DicB- and MinD-dependent division inhibition by inactivation of the minC gene product.
J Bacteriol. 1990 Oct ;172(10):5852-5.

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