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Sci Signal. 2011 Nov 22;4(200):pt8. doi: 10.1126/scisignal.2002434.

Direct delivery mechanisms of morphogen dispersion.

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  • 1Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA.

Abstract

This Presentation focuses on how morphogen signaling proteins disperse across developmental fields. Although the steady-state distributions of morphogen signaling proteins have been described well in a number of contexts, the mechanisms that generate these distributions have remained uncertain. Results presented here show that these proteins transfer from producing to target cells at points of direct contact, even when the producing and target cells are not immediate neighbors.

PMID:
22114143
[PubMed - indexed for MEDLINE]

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