Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Brachial Plex Peripher Nerve Inj. 2011 Nov 23;6:11. doi: 10.1186/1749-7221-6-11.

Neurotrophic effects of perfluorocarbon emulsion gel: a pilot study.

Author information

  • 1Division of Hand Surgery, Department of Orthopaedic Surgery, Virginia Commonwealth University Health Systems, 1200 East Broad Street, P,O, Box 980153, Richmond, VA, USA. jisaacs@mcvh-vcu.edu.

Abstract

BACKGROUND:

Positive neurotrophic effects of hyperbaric oxygen treatment may be more easily achieved by applying a Perflourocarbon (PFC) emulsion gel to the repair site. PFCs are halogen substituted carbon oils with unique oxygen transport potentials that are capable of increasing oxygen availability in local tissues. The purpose of this study was to determine if the application of a PFC emulsion to a repaired nerve would improve recovery.

MATERIALS AND METHODS:

The left tibial nerve of 21 immature female Sprague-Dawley rats was transected, immediately repaired, and then circumferentially coated with PFC gel (Group A, n = 7), PFC-less gel (Group B, n = 7), or nothing (suture only, Group C, n = 7). At eight weeks post surgery, electrophysiological testing and histological and morphological analysis was performed.

RESULTS:

No statistically significant differences between experimental groups were found for muscle size and weight, axon counts, or nerve conduction velocity. Group A had a significantly smaller G-ratio than Groups B and C (p < .0001).

CONCLUSION:

Overall results do not indicate a functional benefit associated with application of a PFC emulsion gel to rodent tibial nerve repairs. A positive effect on myelination was seen.

PMID:
22112536
[PubMed]
PMCID:
PMC3240824
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk