Expanding the azaspiro[3.3]heptane family: synthesis of novel highly functionalized building blocks

Johannes A Burkhard; Carine Guérot; Henner Knust; Erick M Carreira

doi:10.1021/ol2028459

Expanding the azaspiro[3.3]heptane family: synthesis of novel highly functionalized building blocks

Org Lett. 2012 Jan 6;14(1):66-9. doi: 10.1021/ol2028459. Epub 2011 Nov 23.

Authors

Johannes A Burkhard¹, Carine Guérot, Henner Knust, Erick M Carreira

Affiliation

¹ Laboratorium für Organische Chemie, ETH Zürich, CH-8093 Zürich, Switzerland, and F. Hoffmann-La Roche AG, pRED, Discovery Chemistry, CH-4070 Basel, Switzerland.

PMID: 22111917
DOI: 10.1021/ol2028459

Abstract

The preparation of versatile azaspiro[3.3]heptanes carrying multiple exit vectors is disclosed. Expedient synthetic routes enable the straightforward access to these novel modules that are expected to have significance in drug discovery and design.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aza Compounds / chemical synthesis*
Ethers, Cyclic / chemistry
Heptanes / chemical synthesis*
Models, Molecular
Molecular Structure
Spiro Compounds / chemical synthesis*

Substances

Aza Compounds
Ethers, Cyclic
Heptanes
Spiro Compounds
oxetane