Abstract
LYR motif containing 1 (LYRM1) is a novel gene that is abundantly expressed in the adipose tissue of obese subjects and is involved in insulin resistance. In this study, free fatty acids (FFAs) and tumor necrosis factor-α (TNF-α) are shown to upregulate LYRM1 mRNA expression in 3T3-L1 adipocytes. Conversely, resistin and rosiglitazone exert an inhibitory effect on LYRM1 mRNA expression. These results suggest that the expression of LYRM1 mRNA is affected by a variety of factors that are related to insulin sensitivity. LYRM1 may be an important mediator in the development of obesity-related insulin resistance.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3T3-L1 Cells
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Adipokines / pharmacology*
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Animals
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Apoptosis Regulatory Proteins / genetics*
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Fatty Acids, Nonesterified / pharmacology*
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Gene Expression Regulation / drug effects*
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Insulin Resistance / genetics
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Mice
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RNA, Messenger / analysis
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Resistin / pharmacology
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Rosiglitazone
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Thiazolidinediones / pharmacology*
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Tumor Necrosis Factor-alpha / pharmacology
Substances
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Adipokines
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Apoptosis Regulatory Proteins
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Fatty Acids, Nonesterified
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LYR motif containing 1 protein, mouse
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RNA, Messenger
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Resistin
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Thiazolidinediones
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Tumor Necrosis Factor-alpha
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Rosiglitazone