Abstract
Aromatase is expressed in multiple tissues, indicating a crucial role for locally produced oestrogens in the differentiation, regulation and normal function of several organs and processes. This review is an overview of the role of aromatase in different tissues under normal physiological conditions and its contribution to the development of some oestrogen-related pathologies.
Copyright © 2011 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Adipose Tissue / enzymology
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Adipose Tissue / pathology
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Androgens / physiology
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Animals
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Aromatase / physiology*
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Bone and Bones / enzymology
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Bone and Bones / pathology
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Brain / physiology*
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Breast Neoplasms / enzymology
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Breast Neoplasms / pathology
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Endometriosis / enzymology
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Endometriosis / pathology
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Estrogens / physiology*
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Female
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Gonads / physiology*
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Humans
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Male
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Placenta / physiology
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Pregnancy
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Prostate / physiology
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Reproduction / physiology*
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Sexual Behavior
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Sexual Behavior, Animal
Substances
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Androgens
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Estrogens
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Aromatase