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Antimicrob Agents Chemother. 2012 Feb;56(2):1142-5. doi: 10.1128/AAC.05649-11. Epub 2011 Nov 21.

Phenylethyl butyrate enhances the potency of second-line drugs against clinical isolates of Mycobacterium tuberculosis.

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  • 1Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.

Abstract

Ethionamide (ETH) is a second-line drug for the treatment of tuberculosis. As a prodrug, ETH has to be activated by EthA. ethA is controlled by its repressor EthR. 2-Phenylethyl-butyrate (2-PEB) inhibits EthR binding, enhances expression of EthA, and thereby enhances the growth-inhibitory effects of ethionamide, isoxyl, and thiacetazone in Mycobacterium tuberculosis strains with resistance to ETH due to inhA promoter mutations but not ethA mutations.

PMID:
22106218
[PubMed - indexed for MEDLINE]
PMCID:
PMC3264283
Free PMC Article
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