Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Immunol. 2011 Dec 15;187(12):6428-36. doi: 10.4049/jimmunol.1101459. Epub 2011 Nov 21.

p53 serves as a host antiviral factor that enhances innate and adaptive immune responses to influenza A virus.

Author information

  • 1Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA.

Abstract

Several direct target genes of the p53 tumor suppressor have been identified within pathways involved in viral sensing, cytokine production, and inflammation, suggesting a potential role of p53 in antiviral immunity. The increasing need to identify immune factors to devise host-targeted therapies against pandemic influenza A virus (IAV) led us to investigate the role of endogenous wild-type p53 on the immune response to IAV. We observed that the absence of p53 resulted in delayed cytokine and antiviral gene responses in lung and bone marrow, decreased dendritic cell activation, and reduced IAV-specific CD8(+) T cell immunity. Consequently, p53(-/-) mice showed a more severe IAV-induced disease compared with their wild-type counterparts. These findings establish that p53 influences the antiviral response to IAV, affecting both innate and adaptive immunity. Thus, in addition to its established functions as a tumor suppressor gene, p53 serves as an IAV host antiviral factor that might be modulated to improve anti-IAV therapy and vaccines.

PMID:
22105999
[PubMed - indexed for MEDLINE]
PMCID:
PMC3275346
Free PMC Article

Images from this publication.See all images (6)Free text

FIGURE 1
FIGURE 2
FIGURE 3
FIGURE 4
FIGURE 5
FIGURE 6

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk