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Biochem Soc Trans. 2011 Dec;39(6):1742-6. doi: 10.1042/BST20110656.

Nuclear envelope influences on cell-cycle progression.

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  • 1Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, U.K.


The nuclear envelope is a complex double membrane system that serves as a dynamic interface between the nuclear and cytoplasmic compartments. Among its many roles is to provide an anchor for gene regulatory proteins on its nucleoplasmic surface and for the cytoskeleton on its cytoplasmic surface. Both sets of anchors are proteins called NETs (nuclear envelope transmembrane proteins), embedded respectively in the inner or outer nuclear membranes. Several lines of evidence indicate that the nuclear envelope contributes to cell-cycle regulation. These contributions come from both inner and outer nuclear membrane NETs and appear to operate through several distinct mechanisms ranging from sequestration of gene-regulatory proteins to activating kinase cascades.

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