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Adv Mater. 2011 Dec 15;23(47):5684-8. doi: 10.1002/adma.201103316. Epub 2011 Nov 21.

Nanomechanics of streptavidin hubs for molecular materials.

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  • 1Department of Mechanical Engineering and Materials Science, Center for Biologically Inspired Materials and Material Systems, Duke University, Durham, NC 27708, USA.

Abstract

A new strategy is reported for creating protein-based nanomaterials by genetically fusing large polypeptides to monomeric streptavidin and exploiting the propensity of streptavidin monomers(SM) to self-assemble into stable tetramers. We have characterized the mechanical properties of streptavidin-linked structures and measured, for the first time, the mechanical strength of streptavidin tetramers themselves. Using streptavidin tetramers as molecular hubs offers a unique opportunity to create a variety of well-defined, self-assembled protein-based (nano)materials with unusual mechanical properties.

Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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