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Cell Host Microbe. 2011 Nov 17;10(5):423-5. doi: 10.1016/j.chom.2011.10.008.

Porphyromonas gingivalis sinks teeth into the oral microbiota and periodontal disease.

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  • 1Department of Immunology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan. kenya@m.u-tokyo.ac.jp


Periodontitis is linked to polymicrobial interactions and the presence of Porphyromonas gingivalis. In this issue of Cell Host & Microbe, Hajishengallis et al. (2011) demonstrate that P. gingivalis colonization in the oral cavity changes the composition of the oral commensal microbiota and accelerates microbiota-mediated bone-destructive periodontitis, indicating that this single, low-abundance species is a keystone in periodontal disease.

Copyright © 2011 Elsevier Inc. All rights reserved.

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