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    Transplant Proc. 2011 Nov;43(9):3296-8.

    Resolution of long-standing necrobiosis lipoidica diabeticorum (NLD) lesion after restoration of euglycemia following successful pancreas after kidney (PAK) transplantation: a case report.

    Mazur MJ, Lowney AC, Prigoff J, Heilman RL, Chakkera H, Moss A, Mulligan D, Reddy K, Hamawi K.

    Source

    Department of Nephrology, Cork University Hospital, Wilton, Cork, Ireland. marek.mazur@hse.ie

    Abstract

    Necrobiosis lipoidica diabeticorum (NLD) is an inflammatory skin disorder of unknown cause which can be seen in patients with diabetes mellitus. Various treatments, including immunosuppressive agents have been tried, without consistent efficacy. NLD is generally thought not to correlate well with tight diabetic control. Pancreas transplantation is the only widely and clinically used treatment that restores euglycemia in type I diabetic recipients. We report a case of resolution of NLD that had been unchanged for decades before pancreas after kidney transplantation. Another unique aspect of our case was that immunosuppression was discounted as a confounding factor, because the patient had been exposed to the same antirejection regimen for 3 years preceding the pancreas transplantation.

    Copyright © 2011 Elsevier Inc. All rights reserved.

    PMID:
    22099781
    [PubMed - in process]

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