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Exp Neurol. 1990 Sep;109(3):269-72.

Ultrastructural evidence for serotonin-immunoreactive terminals contacting phrenic motoneurons in the cat.

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  • 1Department of Pharmacology, College of Medicine, University of Kentucky, Lexington 40536.


The innervation of the phrenic motor nucleus in the cat by serotonin-containing neurons has been studied using retrograde tracing combined with immunohistochemistry at the electron microscope level. It was found that phrenic motoneuron cell bodies and dendrites are contacted by serotonin-immunoreactive synaptic terminals. This finding suggests that the activity of phrenic motoneurons is directly affected by serotonergic neurons.

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