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Adv Mater. 2011 Dec 15;23(47):5645-50. doi: 10.1002/adma.201103505. Epub 2011 Nov 18.

Magnetic nanocarriers with tunable pH dependence for controlled loading and release of cationic and anionic payloads.

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  • 1Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.


Superparamagnetic nanocarriers with tunable pH dependence of the surface charge are designed by a simple co-precipitation method. By exploiting electrostatic interactions, cationic or anionic payloads can be adsorbed and desorbed depending on the pH. On three different resulting nanocarrier systems, experiments of loading and release of gold nanoparticles as well as effective siRNA loading and in vitro delivery on human cells are performed.

Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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