Send to

Choose Destination
See comment in PubMed Commons below
Purinergic Signal. 2012 Feb;8(Suppl 1):27-40. doi: 10.1007/s11302-011-9273-4. Epub 2011 Nov 18.

Measurement of purine release with microelectrode biosensors.

Author information

  • 1School of Life Sciences, University of Warwick, Coventry, UK,


Purinergic signalling departs from traditional paradigms of neurotransmission in the variety of release mechanisms and routes of production of extracellular ATP and adenosine. Direct real-time measurements of these purinergic agents have been of great value in understanding the functional roles of this signalling system in a number of diverse contexts. Here, we review the methods for measuring purine release, introduce the concept of microelectrode biosensors for ATP and adenosine and explain how these have been used to provide new mechanistic insight in respiratory chemoreception, synaptic physiology, eye development and purine salvage. We finish by considering the association of purine release with pathological conditions and examine the possibilities that biosensors for purines may one day be a standard part of the clinical diagnostic tool chest.

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Write to the Help Desk