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Cancer Cell. 2011 Nov 15;20(5):559-61. doi: 10.1016/j.ccr.2011.10.027.

Discovery of a secreted tumor suppressor provides a promising therapeutic strategy for follicular lymphoma.

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  • 1Department of Pediatric Oncology, Dana-Farber Cancer Institute, Children's Hospital, Boston and Harvard Medical School, 450 Brookline Avenue, Boston, MA 02115, USA.

Abstract

In a recent paper in Cell, Oricchio et al. identify EPHA7 as a tumor suppressor gene residing in the 6q-deleted region in follicular lymphoma. A truncated EPHA7(TR) isoform is secreted by normal B cells, inhibits EPHA2 signaling, and, as a secreted tumor suppressor protein, has potential as a targeted therapeutic polypeptide.

2011 Elsevier Inc. All rights reserved.

PMID:
22094251
[PubMed]
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