Send to:

Choose Destination
See comment in PubMed Commons below
Cancer Cell. 2011 Nov 15;20(5):559-61. doi: 10.1016/j.ccr.2011.10.027.

Discovery of a secreted tumor suppressor provides a promising therapeutic strategy for follicular lymphoma.

Author information

  • 1Department of Pediatric Oncology, Dana-Farber Cancer Institute, Children's Hospital, Boston and Harvard Medical School, 450 Brookline Avenue, Boston, MA 02115, USA.


In a recent paper in Cell, Oricchio et al. identify EPHA7 as a tumor suppressor gene residing in the 6q-deleted region in follicular lymphoma. A truncated EPHA7(TR) isoform is secreted by normal B cells, inhibits EPHA2 signaling, and, as a secreted tumor suppressor protein, has potential as a targeted therapeutic polypeptide.

2011 Elsevier Inc. All rights reserved.

Free full text

Publication Types

Publication Types

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk