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FEMS Microbiol Lett. 2011 Nov;324(1):1-9. doi: 10.1111/j.1574-6968.2011.02363.x. Epub 2011 Aug 9.

Histoplasma mechanisms of pathogenesis--one portfolio doesn't fit all.

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  • 1Department of Microbiology, The Center for Microbial Interface Biology, Ohio State University, Columbus, OH 43210, USA.

Abstract

Histoplasma capsulatum is the leading cause of endemic mycosis in the world. Analyses of clinical isolates from different endemic regions show important diversity within the species. Recent molecular studies of two isolates, the Chemotype I NAm2 strain G217B and the Chemotype II Panamanian strain G186A, reveal significant genetic, structural, and molecular differences between these representative Histoplasma strains. Some of these variations have functional consequences, representing distinct molecular mechanisms that facilitate Histoplasma pathogenesis. The realization of Histoplasma strain diversity highlights the importance of characterizing Histoplasma virulence factors in the context of specific clinical strain isolates.

© 2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.

PMID:
22092757
[PubMed - indexed for MEDLINE]
PMCID:
PMC3228276
Free PMC Article
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