Lung Cancer. 2012 Apr;76(1):118-22. Epub 2011 Nov 15.

Immunosuppression and lung cancer of donor origin after bilateral lung transplantation.

von Boehmer L, Draenert A, Jungraithmayr W, Inci I, Niklaus S, Boehler A, Hofer M, Stahel R, Soltermann A, van den Broek M, Weder W, Knuth A.

Source

Medical Oncology, University Hospital Zurich, Switzerland. Lotta.vonBoehmer@usz.ch

Abstract

Analysis of databases from transplant recipients revealed a 3-5 fold higher risk to develop de novo malignancies under continued immunosuppression. The underlying mechanisms are poorly understood. Here we describe a patient who received a bilateral lung transplantation for end-stage 'usual interstitial pneumonia' (UIP) resulting in idiopathic lung fibrosis. The recipient presented with a non-small cell lung carcinoma (NSCLC) in the donor lung 7 months later. Molecular and immunological typing of the tumor revealed a cancer of donor origin with a prominent intratumoral immune cell infiltrate without detectable effector function. This is a unique case of de novo outgrowth of a NSCLC of donor origin under continued immunosuppression, supporting the concept of tumor immunosurveillance in vivo.

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Lung Cancer. 2012 May;76(2):259-61.

PMID:: 22088939; [PubMed - in process]

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