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Hepat Mon. 2011 Jun;11(6):459-63.

Prevalence of hepatitis E virus and porcine caliciviruses in pig farms of Guizhou province, China.

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  • 1School of Agriculture and Biology, Shanghai JiaoTong University, Shanghai, China.

Abstract

BACKGROUND:

Hepatitis E virus (HEV) and caliciviruses are enteric pathogens of humans and animals, and pigs have been considered an important reservoir of these viruses.

OBJECTIVES:

The aim of this study is to determine the infection rates of HEV and caliciviruses (sapovirus [SaV] and norovirus [NoV]) in different age groups of pigs in Guizhou province, China, and characterize the strains that are prevalent in this mountainous area.

MATERIALS AND METHODS:

A total of 209 stool samples from healthy pigs of different ages were collected from 6 pig farms in Guizhou province from May to June 2009 and tested for HEV, SaV, and NoV by reverse-transcription polymerase chain reaction (RT-PCR).

RESULTS:

The overall prevalence of porcine HEV and porcine SaV was 6.7% (15/209) and 1.0% (2/209), respectively. No NoV was detected. The prevalence rates of porcine HEV infection were 15.4% in piglets aged < 1 mon (4/26), 6.8% in piglets aged between 1 and 4 mon (3/44), 12.5% in piglets aged ≈ 4 mon (6/48), and 1.1% in sows aged between 6 and 14 mon (2/91). Porcine SaV was detected only in piglets (7.7%, 2/26). All 10 HEV isolates belonged to genotype 4, clustering with a human HEV strain (AF103940) from an adjacent province.

CONCLUSIONS:

This is the first report on the existence of porcine SaV in swine in Guizhou province, China. The clustering of the porcine HEV isolates with a human strain suggests cross-species transmission between swine and humans in this area.

KEYWORDS:

Caliciviruses; Genetic diversity; Hepatitis E virus; Porcine

PMID:
22087178
[PubMed]
PMCID:
PMC3212798
Free PMC Article

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