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Cancer Lett. 2012 Apr 1;317(1):49-55. doi: 10.1016/j.canlet.2011.11.010. Epub 2011 Nov 13.

Transplacental carcinogenesis with dibenzo[def,p]chrysene (DBC): timing of maternal exposures determines target tissue response in offspring.

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  • 1Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.

Abstract

Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received four smaller doses of DBC (3.75mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established carcinogenic responses in the thymus, lung, and liver. However, there was a marked increase in ovarian tumors (females) and hyperplastic testes (males). [(14)C]-DBC (GD 17) dosing revealed transplacental distribution to fetal tissues at 10-fold lower concentrations than in paired maternal tissue and residual [(14)C] 3weeks post-dose. This study highlights the importance of developmental stage in susceptibility to environmental carcinogens.

Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

PMID:
22085489
[PubMed - indexed for MEDLINE]
PMCID:
PMC3269513
Free PMC Article

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