J Cell Biol. 2011 Nov 14;195(4):543-52.

The secret life of α-catenin: moonlighting in morphogenesis.

Source

Molecular and Cellular Pharmacology Program and Department of Zoology, University of Wisconsin-Madison, Madison, WI 53706, USA.

Abstract

Cadherin-based intercellular adhesions are important determinants of proper tissue architecture. These adhesions must be both stable and dynamic to maintain tissue integrity as cells undergo morphogenetic movements during development. The role of α-catenin in this process has been vigorously debated due to conflicting in vitro and in vivo evidence regarding its molecular mechanism of action. Recent data supports the classical view that α-catenin facilitates actin attachments at adherens junctions, but also suggests that α-catenin may act as a force transducer, and may have additional roles in the cytoplasm. These multiple functions for α-catenin converge on the regulation of adhesion and may help to explain its stable yet dynamic nature.

PMID:: 22084304; [PubMed - indexed for MEDLINE]
PMCID:: PMC3257527; [Available on 2012/5/14]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

alpha Catenin

Grant Support

GM058038/GM/NIGMS NIH HHS/United States

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