Chem Pharm Bull (Tokyo). 1990 Jun;38(6):1731-4.

Solution synthesis of human peptide YY (hPYY).

Kitagawa K, Tomoyasu T, Futaki S, Akita T, Higashide S, Inoue K, Tobe T.

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Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.

Abstract

Human peptide YY (hPYY) was synthesized in a conventional manner by assembling six peptide fragments followed by deprotection with 1 M trimethylsilyl trifluoromethanesulfonate (TMSOTf)-thioanisole in trifluoroacetic acid (TFA). After purification by gel-filtration on Sephadex G-25, followed by reversed-phase high-performance liquid chromatography, a highly purified sample of synthetic hPYY was obtained. When administered in dogs, synthetic hPYY was as active as synthetic porcine PYY in terms of the effects on systemic arterial blood pressure, and splanchnic blood flow.

PMID:: 2208387; [PubMed - indexed for MEDLINE]

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Solution synthesis of human neuropeptide Y (hNPY). [Chem Pharm Bull (Tokyo). 1989]
Solution synthesis of human neuropeptide Y (hNPY).
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