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Top Curr Chem. 2012;324:137-62. doi: 10.1007/128_2011_284.

Functional analysis of protein targets by metabolomic approaches.

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  • 1Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St., Cambridge, MA, USA.


Proteomics methods, such as activity-based protein profiling, can be used to connect proteins to biology and disease. Some proteins found through unbiased methods are not well characterized, which makes it difficult to ascertain the role of these proteins. Metabolomics approaches are useful in characterizing proteins that regulate or bind metabolites. Here, we provide examples of the development and use of metabolomics approaches to elucidate protein-metabolite interactions.

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