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Nat Rev Genet. 2011 Nov 15;13(1):7-13. doi: 10.1038/nrg3080.

Uncovering the role of 5-hydroxymethylcytosine in the epigenome.

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  • 1Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK. miguel.branco@babraham.ac.uk


Just over 2 years ago, TET1 was found to catalyse the oxidation of 5-methylcytosine, a well-known epigenetic mark, into 5-hydroxymethylcytosine in mammalian DNA. The exciting prospect of a novel epigenetic modification that may dynamically regulate DNA methylation has led to the rapid accumulation of publications from a wide array of fields, from biochemistry to stem cell biology. Although we have only started to scratch the surface, interesting clues on the role of 5-hydroxymethylcytosine are quickly emerging.

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